Inappropriate Complement Activation by Medical Device Materials

Author: Dan Lyle, Ph.D.
Molecular Biology Branch
Division of Life Sciences
OST/CDRH

Start Presentation

Table of Contents

  1. Inappropriate Complement Activation by Medical Device Materials
  2. Anything that contacts blood has potential to activate complement
  3. Examples of Medical Devices That May Activate Complement Inappropriately
  4. Complement Activation Pathways
  5. Primary Function
  6. Chemistry of Activation
  7. Avoiding Inappropriate Complement Activities
  8. How to Test for Complement Activation By Solid (bio)materials
  9. ASTM Standard Practice: F 1984 - 99
  10. Micro Assay for Whole Complement Functional Activation
  11. Remaining Whole Complement Activity after 1h Exposure of Human Serum to Equal Volume of Material
  12. ASTM Standard Practice (Draft)
  13. C4-genetically deficient Guinea Pig Serum:
  14. Alternative C' Assay of Human Serum and C4- Guinea Pig Serum priorly exposed to Zymosan, HAGG, and Sepharose
  15. Present Objectives

| MATES June 15th Meeting Agenda |